When it comes to losing weight, most people focus on food—but what you drink can be just as important, especially if you’re taking prescription weight loss medications. Some beverages can enhance the benefits of these medications by supporting hydration, metabolism, and nutrient absorption, while others may hinder your progress or trigger unwanted side effects.
Whether you’re on GLP-1 receptor agonists like semaglutide or another weight loss drug, choosing the right drinks can make a big difference in your overall results.
What Are Weight Loss Medications?
Prescription weight loss medications are designed to support people who struggle to lose weight through diet and lifestyle changes alone. These drugs typically help by:
- Reducing appetite
- Slowing digestion
- Regulating blood sugar levels
Some, like GLP-1 medications, have added benefits for individuals managing type 2 diabetes, since they lower blood glucose while promoting sustainable weight loss.
“These medications make it easier to maintain a lower-calorie diet and stick with it long-term,” says Melissa Mitri, M.S., RD, a registered dietitian and nutrition writer.
5 Best Drinks to Have While Taking Weight Loss Medications
1. Water – The Ultimate Hydration Powerhouse
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Plain water remains the most essential beverage. It’s calorie-free, supports digestion, helps stabilize blood sugar levels, and prevents dehydration, a common concern when on certain medications.
✅ Tip: Aim for at least 8 glasses a day, and infuse with lemon, cucumber, or mint for extra flavor—without added sugar.
2. Seltzer – A Bubbly, Sugar-Free Swap
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If you crave carbonation, opt for unsweetened seltzer. It offers the hydration benefits of water with a fizzy twist, and may help reduce mild nausea or digestive discomfort, common side effects of GLP-1s.
✅ Choose naturally flavored versions without artificial sweeteners or added sugars.
3. Green Tea – Boost Your Metabolism Naturally
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Rich in antioxidants like EGCG, green tea supports fat oxidation and calorie burning. Studies show it may increase daily energy expenditure by up to 4%, making it a great option to pair with your medication.
✅ Drink it unsweetened—hot or iced—for best results.
4. Black Coffee – A Metabolism and Energy Enhancer
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Black coffee, when consumed in moderation, is virtually calorie-free and may stimulate fat burning, especially during exercise. It can also provide a mental and physical boost without sabotaging your weight loss plan.
✅ Skip the sugar, creamers, and flavored syrups to keep it weight-loss friendly.
5. Protein Shakes – Nutrient-Rich and Filling
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If your appetite is lower due to medication, high-protein shakes can help you meet your daily protein goals while staying full and energized. They also support muscle preservation during weight loss.
✅ Look for protein powders with at least 20g of protein and minimal added sugar.
Try whey or plant-based options and blend them into smoothies with fruit or nut butter for a more satisfying meal or snack.
Final Thoughts: What to Drink When Taking Weight Loss Medications
Choosing the right drinks can significantly enhance your weight loss journey when using medications. Staying hydrated with water, seltzer, or green tea supports your body’s natural fat-burning processes, while protein shakes and black coffee help balance nutrient intake and metabolism.
Before making changes to your diet while on medication, consult your healthcare provider or a registered dietitian to ensure your choices support your unique health needs.
